The Molecular Diagnostics Laboratory is seeking an experienced Variant Scientist to join our clinical team. In this critical role, you will curate and interpret germline and somatic variants and prepare high-quality clinical reports derived from exome and targeted cancer sequencing assays. You will contribute to variant classification, test development efforts, and clinical research projects that advance precision medicine for patients across UCLA Health and beyond. Primary duties include:
•Review and assess patient clinical notes and sequencing data from high-complexity molecular assays, including Clinical Exome Sequencing, Solid Tumor Sequencing Panels, and Hematologic Malignancy Sequencing Panels.
•Perform variant curation and interpretation using established guidelines and evidence-based resources.
•Draft and refine clinical reports, ensuring accuracy, clarity, and clinical relevance.
•Develop and update SOPs for variant curation, interpretation, and reclassification workflows
•Participate in submitting curated variants to public databases (e.g. ClinVar) and contribute to quality improvement and test development initiatives.
•Collaborate with clinicians, genetic counselors, and laboratory staff to support accurate and timely reporting.
•Contribute to clinical research projects and assist in implementing new molecular diagnostic assays.
Salary Range: $105,700.00 - $234,500.00/year
Qualifications
•At least two years’ experience in germline variant curation is required. Somatic variant curation experience is a plus.
•Strong working knowledge of laboratory genetics and genomics, including target capture, amplification, and massively parallel sequencing.
•Familiarity with widely used genomic tools such as IGV and UCSC/COSMIC genome browsers
•Ability to establish effective working relationships with clinicians, genetic counselors, and other team members.
•PhD in human genetics, molecular genetics, cancer biology, or a related discipline - preferred. Master’s degree in molecular biology, genetics, or a closely related field may be considered with relevant experience.
At UCLA Health, you can help heal humankind, one patient at a time by improving health, alleviating suffering and delivering acts of kindness. As you do, you’ll achieve great things in your life and your career. We’re a world-class health organization with four hospitals consistently recognized among the nation’s very best as well as an internationally-renowned medical school, primary and specialty care clinics and much more. Within our dynamic, innovative and growing organization, you’ll find exceptional opportunities to make the most of your abilities in a supportive, empowering and inclusive environment. If you embrace our values of Integrity, Compassion, Respect, Teamwork, Excellence and Discovery we invite you to see all you can accomplish at UCLA Health.
